PanelApp (test)
  1. Genes and Genomic Entities
  2. SDHB:Ensemblv90

SDHB:Ensemblv90

succinate dehydrogenase complex iron sulfur subunit B
OMIM: 185470, ClinGen, DECIPHER

20 panels

Panel Reviews Mode of inheritance Details
20 panels

Green SDHB in Incidentalome


Version 0.370

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Melbourne Genomics Health Alliance
  • Victorian Clinical Genetics Services
Phenotypes
  • Paragangliomas 4, MIM# 115310

Green SDHB in Cancer Predisposition_Paediatric


Level 2: Cancer
Version 0.132

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Paragangliomas 4, MIM# 115310

Green SDHB in Mitochondrial disease


Level 2: Metabolic disorders
Version 0.1299

Component of the following Super Panels:

  • Metabolic Disorders Superpanel
  • Progressive Neurological Conditions

    		•  1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • Australian Genomics Health Alliance Mitochondrial Flagship
    Phenotypes
    • Mitochondrial complex II deficiency, nuclear type 4, MIM# 619224
    • Complex II deficiency
    • mitochondrial leucoencephalopathy

    Green SDHB in Additional findings_Adult


    Level 2: Screening
    Version 1.130

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Melbourne Genomics Health Alliance
    Phenotypes
    • Paragangliomas 4, MIM# 115310

    Green SDHB in Leukodystrophy - paediatric


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.334

    Component of the following Super Panels:

  • Leukodystrophy_Superpanel
  • Progressive Neurological Conditions

    		•  1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Royal Melbourne Hospital
    • Australian Genomcis Health Alliance Leukodystrophy Flagship
    • Victorian Clinical Genetics Services
    Phenotypes
    • Succinate dehydrogenase-deficient leukoencephalopathy
    • Mitochondrial complex II deficiency, nuclear type 4, MIM# 619224
    • Complex II deficiency
    • mitochondrial leucoencephalopathy

    Red SDHB in CGC_86


    Version 0.3

    		0 reviews Other
    Sources
    • CGC_86
    Phenotypes
    • Hereditary Paraganglioma-Pheochromocytoma Syndromes
    • Paraganglioma and gastric stromal sarcoma

    Red SDHB in NCGC


    Version 0.3

    		0 reviews Other
    Sources
    • NCGC
    Phenotypes
    • Hereditary Paraganglioma-Pheochromocytoma Syndromes
    • Paraganglioma and gastric stromal sarcoma

    Red SDHB in TCGA_PANCAN_2018


    Version 0.3

    		0 reviews Other
    Sources
    • TCGA_PANCAN_2018
    Phenotypes
    • Paraganglioma and gastric stromal sarcoma
    • Hereditary Paraganglioma-Pheochromocytoma Syndromes

    Green SDHB in Renal cancer


    Level 2: Cancer susceptibility
    Version 0.5

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • SA Pathology
    Phenotypes
    • Paragangliomas 4, renal cell carcinoma

    Amber SDHB in Additional findings_Paediatric


    Level 2: Screening
    Version 0.278

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Amber
    • BabySeq Category B gene
    Phenotypes
    • Hereditary Paraganglioma-Pheochromocytoma Syndromes

    Amber SDHB in Incidentalome_PREGEN_DRAFT


    Version 0.43

    		1 review Unknown
    Sources
    • Expert Review Amber
    • NSW Health Pathology

    Amber SDHB in Genomic newborn screening: BabyScreen+


    Level 2: Screening
    Version 1.141

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • BabySeq Category B gene
    • Expert Review Amber
    Phenotypes
    • Hereditary Paraganglioma-Pheochromocytoma Syndromes

    Green SDHB in Transplant Co-Morbidity


    Level 2: Screening
    Version 0.20

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Melbourne Genomics Health Alliance
    Phenotypes
    • Paragangliomas 4, MIM# 115310

    Green SDHB in Incidentalome


    Version 1.0

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Victorian Clinical Genetics Services
    • Melbourne Genomics Health Alliance
    • Expert Review Green
    Phenotypes
    • Paragangliomas 4, MIM# 115310

    Green SDHB in Cancer Predisposition_Paediatric


    Level 2: Cancer
    Version 1.0

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green
    Phenotypes
    • Paragangliomas 4, MIM# 115310

    Green SDHB in Additional findings_Adult


    Level 2: Screening
    Version 2.0

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Melbourne Genomics Health Alliance
    • Expert Review Green
    Phenotypes
    • Paragangliomas 4, MIM# 115310

    Green SDHB in Leukodystrophy - paediatric


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.0

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Victorian Clinical Genetics Services
    • Australian Genomcis Health Alliance Leukodystrophy Flagship
    • Royal Melbourne Hospital
    • Expert Review Green
    Phenotypes
    • Succinate dehydrogenase-deficient leukoencephalopathy
    • Mitochondrial complex II deficiency, nuclear type 4, MIM# 619224
    • Complex II deficiency
    • mitochondrial leucoencephalopathy

    Green SDHB in Renal cancer


    Level 2: Cancer susceptibility
    Version 1.0

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • SA Pathology
    • Expert Review Green
    Phenotypes
    • Paragangliomas 4, renal cell carcinoma

    Amber SDHB in Genomic newborn screening: BabyScreen+


    Level 2: Screening
    Version 2.0

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Amber
    • BabySeq Category B gene
    Phenotypes
    • Hereditary Paraganglioma-Pheochromocytoma Syndromes

    Green SDHB in Transplant Co-Morbidity


    Level 2: Screening
    Version 1.0

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Melbourne Genomics Health Alliance
    • Expert Review Green
    Phenotypes
    • Paragangliomas 4, MIM# 115310