PanelApp (test)
  1. Genes and Genomic Entities
  2. NRAS:Ensemblv90

NRAS:Ensemblv90

NRAS proto-oncogene, GTPase
OMIM: 164790, ClinGen, DECIPHER

28 panels

Panel Reviews Mode of inheritance Details
28 panels

Green NRAS in Vasculitis


Level 2: Immunological disorders
Version 0.95

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green NRAS in Congenital Heart Defect


Level 2: Cardiovascular disorders
Version 0.511

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green NRAS in Hydrops fetalis


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.328

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green NRAS in Macrocephaly_Megalencephaly


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.153

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green NRAS in Mendeliome


Version 1.3802

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Noonan syndrome 6, MIM# 613224

Green NRAS in Cancer Predisposition_Paediatric


Level 2: Cancer
Version 0.132

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green NRAS in Rasopathy


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.111

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Noonan syndrome 6, MIM# 613224

Green NRAS in Calcium and Phosphate disorders


Level 2: Renal and urinary tract disorders; Endocrine disorders
Version 1.29

1 review Other
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Costello syndrome MONDO:0009026

Green NRAS in Callosome


Level 2: Neurology and neurodevelopmental disorders
Version 0.578

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green NRAS in Intellectual disability syndromic and non-syndromic


Level 2: Neurology and neurodevelopmental disorders
Version 1.508

1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Genetic Health Queensland
Phenotypes
  • Noonan syndrome 6, MIM# 613224

Red NRAS in Vascular Malformations_Germline


Level 2: Cardiovascular disorders
Version 1.12

Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  1 review Other
    Sources
    • Expert Review Red
    • Expert list
    Phenotypes
    • Kaposiform lymphangiomatosis
    • Sporadic vascular malformation
    Tags
    • somatic

    Red NRAS in TCGA_PANCAN_2018


    Version 0.3

    		0 reviews Other
    Sources
    • TCGA_PANCAN_2018
    Phenotypes
    • Congenital giant melanocytic nevus
    • Rasopathy
    • RAS-associated autoimmune leukoproliferative disorder
    • NA
    • Noonan syndrome 6
    • Epidermal nevus

    Green NRAS in Lymphoedema_syndromic

    Level 3: Lymphatic Disorders
    Level 2: Cardiovascular disorders
    Version 0.12

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  0 reviews MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Expert Review
    Phenotypes
    • Noonan syndrome 6 613224

    Green NRAS in Vascular Malformations_Somatic


    Level 2: Cardiovascular disorders
    Version 1.16

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  1 review Other
    Sources
    • Expert Review Green
    • Expert list
    • Expert list
    Phenotypes
    • Kaposiform lymphangiomatosis
    • Sporadic vascular malformation
    Tags
    • somatic

    Green NRAS in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 0.208

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • South West GLH
    • NHS GMS
    • Expert Review Green
    • Expert List
    • London South GLH
    Phenotypes
    • Noonan syndrome 6 613224
    • CFC Syndrome
    • Cardio-Facio-cutanenous syndrome
    • syndromic HCM
    • Noonan syndrome 6
    • Noonan syndrome

    Green NRAS in Mosaic skin disorders


    Level 2: Dermatological disorders
    Version 1.15

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  2 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • NHS GMS
    Phenotypes
    • Noonan syndrome
    • Melanocytic naevi
    • Congenital melanocytic naevus syndrome
    Tags
    • somatic

    Green NRAS in Growth failure


    Version 1.87

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    Phenotypes
    • Noonan syndrome 6, MIM# 613224

    Green NRAS in Fetal anomalies


    Version 1.482

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    Phenotypes
    • Noonan syndrome 6, MIM# 613224

    Green NRAS in Vasculitis


    Level 2: Immunological disorders
    Version 1.0

    		0 reviews Unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services

    Green NRAS in Congenital Heart Defect


    Level 2: Cardiovascular disorders
    Version 1.0

    		0 reviews Unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services

    Green NRAS in Macrocephaly_Megalencephaly


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 1.0

    		0 reviews Unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services

    Green NRAS in Cancer Predisposition_Paediatric


    Level 2: Cancer
    Version 1.0

    		0 reviews Unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services

    Green NRAS in Rasopathy


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 1.0

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green
    Phenotypes
    • Noonan syndrome 6, MIM# 613224

    Green NRAS in Calcium and Phosphate disorders


    Level 2: Renal and urinary tract disorders; Endocrine disorders
    Version 2.0

    		1 review Other
    Sources
    • Literature
    • Expert Review Green
    Phenotypes
    • Costello syndrome MONDO:0009026

    Green NRAS in Callosome


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.0

    		0 reviews Unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services

    Green NRAS in Lymphoedema_syndromic

    Level 3: Lymphatic Disorders
    Level 2: Cardiovascular disorders
    Version 1.0

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review
    • Expert Review Green
    Phenotypes
    • Noonan syndrome 6 613224

    Green NRAS in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 1.0

    		0 reviews MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • London South GLH
    • Expert List
    • Expert Review Green
    • NHS GMS
    • South West GLH
    Phenotypes
    • Noonan syndrome 6 613224
    • CFC Syndrome
    • Cardio-Facio-cutanenous syndrome
    • syndromic HCM
    • Noonan syndrome 6
    • Noonan syndrome

    Green NRAS in Growth failure


    Version 2.0

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Victorian Clinical Genetics Services
    • Genomics England PanelApp
    • Expert Review Green
    Phenotypes
    • Noonan syndrome 6, MIM# 613224