MSH6

mutS homolog 6
OMIM: 600678, ClinGen, DECIPHER

18 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 18 panels
Green MSH6 in Incidentalome Version 1.0	1 review	Unknown	Sources Expert Review Green Melbourne Genomics Health Alliance Victorian Clinical Genetics Services Expert Review Green
Green MSH6 in Cancer Predisposition_Paediatric Level 2: Cancer Version 1.0	0 reviews	Unknown	Sources Victorian Clinical Genetics Services Expert Review Green
Red MSH6 in Callosome Level 2: Neurology and neurodevelopmental disorders Version 1.0	0 reviews	Unknown	Sources Expert Review Red Victorian Clinical Genetics Services
Green MSH6 in Additional findings_Adult Level 2: Screening Version 2.0	1 review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Melbourne Genomics Health Alliance Phenotypes Colorectal cancer, hereditary nonpolyposis, type 5, MIM# 614350
Red MSH6 in Predominantly Antibody Deficiency Level 2: Immunological disorders Version 2.0	1 review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Expert list Phenotypes Mismatch repair cancer syndrome 3 MIM#619097 constitutional mismatch repair deficiency immunodeficiency
Red MSH6 in Intellectual disability syndromic and non-syndromic Level 2: Neurology and neurodevelopmental disorders Version 2.0	1 review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red Expert list Phenotypes Colorectal cancer, hereditary nonpolyposis, type 5, OMIM #614350 Mismatch repair cancer syndrome, OMIM #276300
Green MSH6 in Medulloblastoma Level 2: Cancer Predisposition Version 2.0	1 review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Expert Review Green Expert Review Expert list Phenotypes Medulloblastoma, MONDO:0007959 Lynch syndrome 5, MONDO:0013710 Mismatch repair cancer syndrome 3, MONDO:0030841 Lynch syndrome 5, MIM#614350 Mismatch repair cancer syndrome 3, MIM#619097
Red MSH6 in Additional findings_Paediatric Level 2: Screening Version 1.0	0 reviews	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red BabySeq Category C gene Phenotypes Lynch syndrome
Green MSH6 in Incidentalome_PREGEN_DRAFT Version 1.0	0 reviews	Unknown	Sources NSW Health Pathology Expert Review Green
Green MSH6 in Genomic newborn screening: BabyScreen+ Level 2: Screening Version 2.0	1 review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green BabySeq Category C gene Phenotypes Mismatch repair cancer syndrome 3, MIM# 619097 Tags treatable cancer
Green MSH6 in Transplant Co-Morbidity Level 2: Screening Version 1.0	0 reviews	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Melbourne Genomics Health Alliance Phenotypes Colorectal cancer, hereditary nonpolyposis, type 5, MIM# 614350
Green MSH6 in Sarcoma soft tissue Level 2: Cancer Predisposition Version 2.0	1 review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Expert Review Expert list Phenotypes Soft tissue sarcoma, MONDO:0018078 Sarcoma, MONDO:0005089 Mismatch repair cancer syndrome 3, MONDO:0030841 Mismatch repair cancer syndrome 3, MIM#619097
Green MSH6 in Pancreatic Cancer Level 2: Cancer Predisposition Version 2.0	1 review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Expert Review Green Expert Review Expert list Phenotypes Malignant pancreatic neoplasm, MONDO:0009831 Lynch syndrome 5, MONDO:0013710 Mismatch repair cancer syndrome 3, MONDO:0030841 Lynch syndrome 5, MIM#614350 Mismatch repair cancer syndrome 3, MIM#619097
Green MSH6 in Colorectal Cancer and Polyposis Level 2: Cancer Predisposition Version 2.0	1 review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Expert Review Green Expert Review Expert list Phenotypes Colorectal cancer, MONDO:0005575 Polyposis, MONDO:0000147 Lynch syndrome 5, MONDO:0013710 Mismatch repair cancer syndrome 3, MONDO:0030841 Lynch syndrome 5, MIM#614350 Mismatch repair cancer syndrome 3, MIM#619097
Green MSH6 in Prostate Cancer Level 2: Cancer Predisposition Version 2.0	1 review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Expert Review Green Expert Review Expert list Phenotypes Prostate cancer, MONDO:0008315 Lynch syndrome 5, MONDO:0013710 Mismatch repair cancer syndrome 3, MONDO:0030841 Lynch syndrome 5, MIM#614350 Mismatch repair cancer syndrome 3, MIM#619097
Green MSH6 in Endometrial Cancer Level 2: Cancer Predisposition Version 2.0	1 review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Expert Review Green Expert Review Expert list Phenotypes Endometrial cancer, MONDO:0011962 Lynch syndrome 5, MONDO:0013710 Mismatch repair cancer syndrome 3, MONDO:0030841 Lynch syndrome 5, MIM#614350 Mismatch repair cancer syndrome 3, MIM#619097
Green MSH6 in Ovarian Cancer Level 2: Cancer Predisposition Version 2.0	1 review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Expert Review Green Expert Review Expert list Phenotypes Ovarian cancer, MONDO:0008170 Lynch syndrome 5, MONDO:0013710 Mismatch repair cancer syndrome 3, MONDO:0030841 Lynch syndrome 5, MIM#614350 Mismatch repair cancer syndrome 3, MIM#619097
Red MSH6 in Breast Cancer Level 2: Cancer Predisposition Version 2.0	1 review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red ClinGen Phenotypes Hereditary breast carcinoma, MONDO:0016419 Tags disputed