PanelApp (test)
  1. Genes and Genomic Entities
  2. LZTR1:Ensemblv90

LZTR1:Ensemblv90

leucine zipper like transcription regulator 1
OMIM: 600574, ClinGen, DECIPHER

28 panels

Panel Reviews Mode of inheritance Details
28 panels

Red LZTR1 in Cerebral Palsy


Level 2: Neurology and neurodevelopmental disorders
Version 1.405

1 review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Literature
Phenotypes
  • Noonan syndrome 2, MIM#605275

Green LZTR1 in Congenital Heart Defect


Level 2: Cardiovascular disorders
Version 0.511

2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Cardiac defects
  • hypertrophic cardiomyopathy
  • atrial septal defect
  • pulmonary stenosis
  • short stature
  • intellectual disabilities

Green LZTR1 in Hydrops fetalis


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.328

1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Noonan syndrome 10
  • Noonan syndrome 2
  • {Schwannomatosis-2, susceptibility to}

Green LZTR1 in Incidentalome


Version 0.370

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green LZTR1 in Macrocephaly_Megalencephaly


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.153

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green LZTR1 in Rasopathy


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.111

1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Noonan syndrome 10
  • Noonan syndrome 2

Green LZTR1 in Callosome


Level 2: Neurology and neurodevelopmental disorders
Version 0.578

0 reviews Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green LZTR1 in Intellectual disability syndromic and non-syndromic


Level 2: Neurology and neurodevelopmental disorders
Version 1.508

1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Noonan syndrome 10, MIM#616564
  • Noonan syndrome 2, MIM#605275

Red LZTR1 in CGC_86


Version 0.3

0 reviews Other
Sources
  • CGC_86
Phenotypes
  • NA

Red LZTR1 in NCGC


Version 0.3

0 reviews Other
Sources
  • NCGC
Phenotypes
  • NA

Green LZTR1 in Lymphoedema_syndromic

Level 3: Lymphatic Disorders
Level 2: Cardiovascular disorders
Version 0.12

Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  0 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review
    Phenotypes
    • Schwannomatosis-2, susceptibility to 615670
    • Noonan syndrome 10 616564

    Green LZTR1 in Schwannomatosis


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.17

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • {Schwannomatosis-2, susceptibility to} MIM#615670

    Green LZTR1 in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 0.208

    		0 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert List
    • NHS GMS
    Phenotypes
    • Schwannomatosis-2, susceptibility to 615670
    • Noonan syndrome 10 616564

    Green LZTR1 in Incidentalome_PREGEN_DRAFT


    Version 0.43

    		0 reviews Unknown
    Sources
    • NSW Health Pathology
    • Expert Review Green

    Green LZTR1 in Growth failure


    Version 1.87

    		1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    Phenotypes
    • Noonan syndrome 10
    • Noonan syndrome 2

    Green LZTR1 in Fetal anomalies


    Version 1.482

    		2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Expert list
    Phenotypes
    • Noonan syndrome 10, MIM#616564
    • Noonan syndrome 2, MIM#605275
    • Fetal hydrops

    Red LZTR1 in Cerebral Palsy


    Level 2: Neurology and neurodevelopmental disorders
    Version 2.0

    		1 review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Literature
    • Expert Review Red
    Phenotypes
    • Noonan syndrome 2, MIM#605275

    Green LZTR1 in Congenital Heart Defect


    Level 2: Cardiovascular disorders
    Version 1.0

    		2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Literature
    • Expert Review Green
    Phenotypes
    • Cardiac defects
    • hypertrophic cardiomyopathy
    • atrial septal defect
    • pulmonary stenosis
    • short stature
    • intellectual disabilities

    Green LZTR1 in Hydrops fetalis


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 1.0

    		1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green
    Phenotypes
    • Noonan syndrome 10
    • Noonan syndrome 2
    • {Schwannomatosis-2, susceptibility to}

    Green LZTR1 in Incidentalome


    Version 1.0

    		0 reviews Unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services

    Green LZTR1 in Macrocephaly_Megalencephaly


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 1.0

    		0 reviews Unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services

    Green LZTR1 in Rasopathy


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 1.0

    		1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green
    Phenotypes
    • Noonan syndrome 10
    • Noonan syndrome 2

    Green LZTR1 in Callosome


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.0

    		0 reviews Unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services

    Green LZTR1 in Lymphoedema_syndromic

    Level 3: Lymphatic Disorders
    Level 2: Cardiovascular disorders
    Version 1.0

    		0 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review
    • Expert Review Green
    Phenotypes
    • Schwannomatosis-2, susceptibility to 615670
    • Noonan syndrome 10 616564

    Green LZTR1 in Schwannomatosis


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.0

    		1 review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert list
    • Expert Review Green
    Phenotypes
    • {Schwannomatosis-2, susceptibility to} MIM#615670

    Green LZTR1 in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 1.0

    		0 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert List
    • Expert Review Green
    Phenotypes
    • Schwannomatosis-2, susceptibility to 615670
    • Noonan syndrome 10 616564

    Green LZTR1 in Growth failure


    Version 2.0

    		1 review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Victorian Clinical Genetics Services
    • Genomics England PanelApp
    • Expert Review Green
    Phenotypes
    • Noonan syndrome 10
    • Noonan syndrome 2

    Green LZTR1 in Fetal anomalies


    Version 2.0

    		2 reviews BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert list
    • Genomics England PanelApp
    • Expert Review Green
    Phenotypes
    • Noonan syndrome 10, MIM#616564
    • Noonan syndrome 2, MIM#605275
    • Fetal hydrops