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Thyroid Cancer v2.0 RET Gene migrated from ENSG00000165731 to ENSG00000165731 (gene set migration)
Thyroid Cancer v2.0 PTEN Gene migrated from ENSG00000171862 to ENSG00000171862 (gene set migration)
Thyroid Cancer v2.0 PRKAR1A Gene migrated from ENSG00000108946 to ENSG00000108946 (gene set migration)
Thyroid Cancer v2.0 DICER1 Gene migrated from ENSG00000100697 to ENSG00000100697 (gene set migration)
Thyroid Cancer v2.0 CDKN1B Gene migrated from ENSG00000111276 to ENSG00000111276 (gene set migration)
Thyroid Cancer v2.0 APC Gene migrated from ENSG00000134982 to ENSG00000134982 (gene set migration)
Thyroid Cancer v2.0 Panel migrated to gene set Ensemblv115. Source version: v1.1
Thyroid Cancer v1.1 Zornitza Stark Panel types changed to Victorian Clinical Genetics Services; Genetic Health Queensland; Cancer Germline; Adult Genetics Unit, Royal Adelaide Hospital
Thyroid Cancer v1.0 Zornitza Stark promoted panel to version 1.0
Thyroid Cancer v0.15 Zornitza Stark Panel status changed from internal to public
Thyroid Cancer v0.13 Zornitza Stark Panel name changed from Thyroid Neoplasm to Thyroid Cancer
Thyroid Cancer v0.12 RET Zornitza Stark Marked gene: RET as ready
Thyroid Cancer v0.12 RET Zornitza Stark Gene: ret has been classified as Green List (High Evidence).
Thyroid Cancer v0.12 PTEN Zornitza Stark Marked gene: PTEN as ready
Thyroid Cancer v0.12 PTEN Zornitza Stark Gene: pten has been classified as Green List (High Evidence).
Thyroid Cancer v0.12 PRKAR1A Zornitza Stark Marked gene: PRKAR1A as ready
Thyroid Cancer v0.12 PRKAR1A Zornitza Stark Gene: prkar1a has been classified as Green List (High Evidence).
Thyroid Cancer v0.12 DICER1 Zornitza Stark Marked gene: DICER1 as ready
Thyroid Cancer v0.12 DICER1 Zornitza Stark Gene: dicer1 has been classified as Green List (High Evidence).
Thyroid Cancer v0.12 CDKN1B Zornitza Stark Marked gene: CDKN1B as ready
Thyroid Cancer v0.12 CDKN1B Zornitza Stark Gene: cdkn1b has been classified as Green List (High Evidence).
Thyroid Cancer v0.12 APC Zornitza Stark Marked gene: APC as ready
Thyroid Cancer v0.12 APC Zornitza Stark Gene: apc has been classified as Green List (High Evidence).
Thyroid Cancer v0.12 APC chirag patel Classified gene: APC as Green List (high evidence)
Thyroid Cancer v0.12 APC chirag patel Gene: apc has been classified as Green List (High Evidence).
Thyroid Cancer v0.11 CDKN1B chirag patel Classified gene: CDKN1B as Green List (high evidence)
Thyroid Cancer v0.11 CDKN1B chirag patel Gene: cdkn1b has been classified as Green List (High Evidence).
Thyroid Cancer v0.10 DICER1 chirag patel Classified gene: DICER1 as Green List (high evidence)
Thyroid Cancer v0.10 DICER1 chirag patel Gene: dicer1 has been classified as Green List (High Evidence).
Thyroid Cancer v0.9 PRKAR1A chirag patel Classified gene: PRKAR1A as Green List (high evidence)
Thyroid Cancer v0.9 PRKAR1A chirag patel Gene: prkar1a has been classified as Green List (High Evidence).
Thyroid Cancer v0.8 PTEN chirag patel Classified gene: PTEN as Green List (high evidence)
Thyroid Cancer v0.8 PTEN chirag patel Gene: pten has been classified as Green List (High Evidence).
Thyroid Cancer v0.7 RET chirag patel Classified gene: RET as Green List (high evidence)
Thyroid Cancer v0.7 RET chirag patel Gene: ret has been classified as Green List (High Evidence).
Thyroid Cancer v0.6 APC chirag patel gene: APC was added
gene: APC was added to Thyroid Neoplasm. Sources: Expert list,Expert Review
Mode of inheritance for gene: APC was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: APC were set to Thyroid cancer, MONDO:0002108; Thyroid gland papillary carcinoma, MONDO:0005075; Familial adenomatous polyposis 1, MONDO:0021056; Adenomatous polyposis coli, MIM#175100
Review for gene: APC was set to GREEN
Added comment: ClinGen definitive. Papillary thyroid cancer reported in condition.
Sources: Expert list, Expert Review
Thyroid Cancer v0.5 CDKN1B chirag patel gene: CDKN1B was added
gene: CDKN1B was added to Thyroid Neoplasm. Sources: Expert list,Expert Review
Mode of inheritance for gene: CDKN1B was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: CDKN1B were set to Thyroid cancer, MONDO:0002108; Thyroid gland papillary carcinoma, MONDO:0005075; Multiple endocrine neoplasia type 4, MONDO:0012552; Multiple endocrine neoplasia, type 4, MIM#610755
Review for gene: CDKN1B was set to GREEN
Added comment: ClinGen definitive. Papillary thyroid cancer reported in condition.
Sources: Expert list, Expert Review
Thyroid Cancer v0.4 DICER1 chirag patel gene: DICER1 was added
gene: DICER1 was added to Thyroid Neoplasm. Sources: Expert list,Expert Review
Mode of inheritance for gene: DICER1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: DICER1 were set to Thyroid cancer, MONDO:0002108; Thyroid gland papillary carcinoma, MONDO:0005075; DICER1-related tumor predisposition, MONDO:0100216; DICER1 syndrome, MIM#601200
Review for gene: DICER1 was set to GREEN
Added comment: ClinGen definitive. Papillary thyroid cancer reported in condition.
Sources: Expert list, Expert Review
Thyroid Cancer v0.3 RET chirag patel changed review comment from: ClinGen definitive. GOF variants.
Sources: Expert list, Expert Review; to: ClinGen definitive. Medullary thyroid cancer reported in condition. GOF variants.
Sources: Expert list, Expert Review
Thyroid Cancer v0.3 PRKAR1A chirag patel gene: PRKAR1A was added
gene: PRKAR1A was added to Thyroid Neoplasm. Sources: Expert list,Expert Review
Mode of inheritance for gene: PRKAR1A was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: PRKAR1A were set to Thyroid cancer, MONDO:0002108; Thyroid gland follicular carcinoma, MONDO:0005034; Carney complex type 1, MONDO:0008057; Carney complex, type 1, MIM#160980
Review for gene: PRKAR1A was set to GREEN
Added comment: ClinGen definitive. Follicular thyroid cancer reported in condition.
Sources: Expert list, Expert Review
Thyroid Cancer v0.2 PTEN chirag patel gene: PTEN was added
gene: PTEN was added to Thyroid Neoplasm. Sources: Expert list,Expert Review
Mode of inheritance for gene: PTEN was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: PTEN were set to Thyroid cancer, MONDO:0002108; Thyroid gland follicular carcinoma, MONDO:0005034; PTEN hamartoma tumor syndrome, MONDO:0017623; PTEN hamartoma tumour syndromes, MIM#158350
Review for gene: PTEN was set to GREEN
Added comment: ClinGen definitive. Follicular thyroid cancer reported in condition.
Sources: Expert list, Expert Review
Thyroid Cancer v0.1 RET chirag patel changed review comment from: ClinGen definitive. Thyroid cancer reported in condition. GOF variants.
Sources: Expert list, Expert Review; to: ClinGen definitive. GOF variants.
Sources: Expert list, Expert Review
Thyroid Cancer v0.1 RET chirag patel gene: RET was added
gene: RET was added to Thyroid Neoplasm. Sources: Expert list,Expert Review
Mode of inheritance for gene: RET was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: RET were set to Thyroid cancer, MONDO:0002108; Medullary thyroid gland carcinoma, MONDO:0015277; Multiple endocrine neoplasia type 2A, MONDO:0008234; Multiple endocrine neoplasia type 2B, MONDO:0008082; Multiple endocrine neoplasia, type 2A, MIM#171400; Multiple endocrine neoplasia, type 2B, MIM#162300; Pheochromocytoma, MIM#171300; Medullary thyroid carcinoma, MIM#155240; Pheochromocytoma, susceptibility to, MIM#171300
Mode of pathogenicity for gene: RET was set to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Review for gene: RET was set to GREEN
Added comment: ClinGen definitive. Thyroid cancer reported in condition. GOF variants.
Sources: Expert list, Expert Review
Thyroid Cancer v0.0 chirag patel Added Panel Thyroid Neoplasm
Set panel types to: Cancer Germline